Aging Impairs Skeletal Muscle Mitochondrial Bioenergetic Function
نویسندگان
چکیده
منابع مشابه
Generation and bioenergetic analysis of cybrids containing mitochondrial DNA from mouse skeletal muscle during aging
Mitochondrial respiratory chain defects have been associated with various diseases and normal aging, particularly in tissues with high energy demands including skeletal muscle. Muscle-specific mitochondrial DNA (mtDNA) mutations have also been reported to accumulate with aging. Our understanding of the molecular processes mediating altered mitochondrial gene expression to dysfunction associated...
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Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial per...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 2009
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/gln048